Osteoclastic or phagocytic resorption suppressed by ZnTCP

Atsuo Ito; Haruo Kawamura; Shunpei Miyakawa; Pierre Layrolle; Noriko Kanzaki; Gabin Treboux; Kazuo Onuma; Sadao Tsutsumi

doi:10.14853/pcersj.2002F.0.15.0

15th Fall Meeting of The Ceramic Society of Japan

DOI https://doi.org/10.14853/pcersj.2002F.0.15.0

Conference information

Host: The Ceramic Society of Japan

Osteoclastic or phagocytic resorption suppressed by ZnTCP

Atsuo Ito, Haruo Kawamura, Shunpei Miyakawa, Pierre Layrolle, Noriko Kanzaki, Gabin Treboux, Kazuo Onuma, Sadao Tsutsumi

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Keywords: Zinc-containing tricalcium phosphate, resorbable, solubility product, animal experiment, osteoclast

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Pages 15

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Abstract

The negative logarithm of the solubility product (Ksp) of ZnTCP was expressed as pKsp = 28.686+1.7414C-0.42239C²+0.063911C³-0.0051037C⁴+0.0001595C⁵ in air, where C is the zinc content in ZnTCP in mol%. The solubility of ZnTCP, containing 0.63 and 0.316 Zn wt%, decreased to 52-69% of the solubility of pure TCP in the pH range of 5.0-7.4. However, the in vivo resorbed volume of ZnTCP containing the same amount of zinc was as low as 26-20% of that of TCP. The reduction of the resorbability of ZnTCP would be attributable principally to its lowered cellular activation property relative to that associated with pure TCP.

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