In vivo evaluation of biocompatibility to hard tissue by implanting injectable hydroxyapatite cement including chitosan into rabbit tibiae

Abstract

Hydroxyapatite (HAp) has been used as bioceramics in which cement has received much attention. Handling feasibility and mechanical strength of cement are important factors for clinical application. In the present study, we used a chitosan as a mixing solution for cement fabrication to enhance those properties. As results, the cement specimen fabricated by injection had maximum compressive strength (22 MPa) in the case of the powder/liquid (P/L) ratio of 1/1.0 [g/cm3]. In vivo evaluation, the implanted cement specimens directly bonded with newly-formed bones. Thus, the chelate-setting HAp cement is promising for clinical application as injectable cement.