2025 Volume 106 Issue 1 Pages 69-71
We report the case of a 70-year-old woman who underwent breast-conserving surgery for right breast cancer. Fourteen years after surgery, elevated CA15-3 levels were detected. A PET/CT scan revealed enhancement in the gastric body, and esophagogastroduodenoscopy showed mild edema and erosions throughout the gastric body. These findings didn't resemble the typical mucosal pattern of gastric cancer. A biopsy of the lesion revealed adenocarcinoma with signet-ring cells, and immunohistochemistry confirmed ER and GATA3 positivity, consistent with gastric metastasis from breast cancer.
The patient was treated with Chemotherapy leading to an initial improvement in endoscopy findings. However, it was discontinued after four months due to drug-induced pneumoniae. Then breast cancer progressed, and erosion worsened.
This case highlights the importance of endoscopic and histopathological evaluation, for the accurate diagnosis of gastric metastasis from breast cancer.
