Two cases of aspirin-induced multiple small bowel ulceration treated with a change in antiplatelet agent

Abstract

We report two cases of aspirin-induced multiple small bowel ulceration treated with antiplatelet agent change. An 83-year-old man and a 75-year-old man were referred to our hospital for evaluation of chronic anemia. Both patients had been diagnosed with acute myocardial infarction and treated with percutaneous coronary intervention a few years previously, and were prescribed aspirin (100 mg/day) . Multiple small bowel ulcers were diagnosed using small bowel capsule endoscopy. After treatment involving a change of aspirin to clopidogrel (75 mg/day) , the multiple small bowel ulcers and chronic anemia improved. Changing aspirin to clopidogrel is thought to be an effective treatment for aspirin-induced multiple small bowel ulceration.