The patient was a 66-year-old male, with the chief complaint of diarrhea. He began experiencing diarrhea at the beginning of September 2012, with the symptom worsening in October, along with the onset of pedal edema and dysgeusia. He was hospitalized in November 2012. Blood biochemistry at the time of hospitalization confirmed hypoalbuminemia, and a colonoscopic examination revealed edematous change of the mucous membrane of the entire large intestine and mucosal hyperpigmentation. Upper gastrointestinal endoscopy revealed the presence of hypertrophic adenomatous polyps from the stomach to the duodenum. Histopathology confirmed severe edema of the mucous membrane of both the upper and lower GI tract, mild to moderate chronic inflammatory cell infiltration and ductal dilatation, consistent with the diagnosis of Cronkhite-Canada syndrome. The patient was then treated with PSL 50 mg/day, and the clinical symptoms and endoscopic findings improved rapidly after the treatment initiation.
