Abstract
A one-week eradication therapy of Helicobacter pylori using metronidazole, clarithromycin, and omeprazole is generally considered a well-tolerated therapy with minor side effects. We report a 66-year-old male patient who developed diarrhea few days after the treatment, and Clostridium difficile toxin was detected in his stool. Although this is a rare complication, it can sometimes occur; therefore, physicians should consider C. difficile colitis a possible side effect when patients present diarrhea after eradication therapy of H. pylori.