A female was admitted presenting with melaena. She had previously been diagnosed with deep vein thrombosis which was being treated with Warfarin. Esophagogastroduodenoscopy revealed a symptomatic submucosal pedunculated tumor located in the second portion of the duodenum. The tumor showed a thick stalk, yellow in color, and measuring 20 mm at its base. Definitive diagnosis of a duodenal lipoma located in the submucosal layer was supported by histological examination. During endoscopic examination blood was discovered issuing from a mucosal break in the stalk. Hemostasis was achieved via hemostatic clips that were administered endoscopically. Eighteen days after undergoing endoscopic hemostasis the patient had melaena again. After the melaena, removal of the duodenal lipoma via endoscopic polypectomy using a detachable snare was determined the choice treatment. After seventeen days the patient showed no postoperative complications and was subsequently discharged. In this case, the use of a detachable snare was determined an effective technique in performing endoscopic polypectomy in the removal of the symptomatic duodenal lipoma.
