We report the first case of biperiden (Tasmolin®) -induced Stevens-Johnson syndrome (SJS) with late complications of gastric ulcer perforation and esophageal stricture. A 53-year-old male with schizophrenia had a fever and skin erythema after biperiden had been administered for 8 weeks. He was admitted, and diagnosed as biperiden-induced SJS. The skin erythema was disappeared after steroid pulse and immunoglobulin combined therapy. On the 22th day, he had melena and anemia. Endoscopic findings revealed the hemorrhagic gastric ulcers and the peelings of esophageal mucosal membrane. He was treated with endoscopic hemostasis and proton pump inhibitor. On the 44th day, gastric ulcer was perforated and treated surgically. On the 126th day, he had dysphagia because of the esophageal stricture. The mucosal inflammation was disappeared and stricture was 1 cm in length. Dysphagia was improved after endoscopic balloon dilation therapy.
