Three whitish lesions on the body of the stomach were detected in the Helicobacter pylori uninfected mucosa of a 71-year-old man who underwent a screening endoscopy. It was difficult to confirm the diagnosis of malignancy by endoscopic biopsy. In a 1-year follow-up biopsy, lesion A was classified as group 5 and lesion B was classified as group 4. Because gastric adenocarcinoma of fundic gland type (GAFG) was suspected based on the biopsy, the patient was referred to our hospital, and he underwent Endoscopic submucosal dissection. Histologically, HE staining determined that these lesions comprised cells resembling chief cells, and the tumor cells were shown to have invaded the submucosa. We diagnosed these lesions as GAFG.
Even though reports of GAFG have increased in recent years, little literature is present on multiple lesions. Herein we report an exceptionally rare case of multiple GAFG.
