Case 1 was a 54-year-old woman who underwent endoscopic mucosal resection for duodenal neoplasm near the papilla. Specimens of the endoscopic surgery scar and papilla were obtained by an esophagogastroduodenoscopy (EGD) . The same afternoon, the patient came back to our department for the chief complaints of epigastralgia and vomiting and was diagnosed with severe acute pancreatitis. Case 2 was a 58-year-old man who underwent an endoscopic papillectomy. An EGD was taken approximately 18 months later to obtain specimens of the endoscopic surgery scar at 2 sites. The same afternoon, the patient came back to our department with the chief complaint of epigastralgia, and the patient was diagnosed with severe acute pancreatitis. It is important to recognize that papillary biopsies always carry a risk of pancreatitis and to inform patients of this possible complication prior to performing the biopsy.
