A 70-year-old man with anemia was found in esophagogastroduodenoscopy to have a Type1 lesion in the gastric body. Biopsy specimens showed poorly differentiated adenocarcinoma. We performed total gastrectomy. Histopathological findings confirmed two types of the feature one was solid nest pattern that was suspected neuroendocrine carcinoma, and another was trabecular pattern that was suspected tubular adenocarcinoma. Immunohistochemically, all of the tumor cells were positive for AFP and synaptophysin, and some of the tumor cells were positive for chromogranin A. We concluded our case was a AFP-producing gastric cancer with neuroendocrine carcinoma.
