A 69-year-old woman visited our hospital for gastric abnormality in the upper gastrointestinal series. She had no subjective symptoms. Blood examination including tumor marker revealed normal levels. A gastrointestinal endoscopic study revealed a stage 0-IIc-like lesion of the stomach body. Histological findings of the biopsy specimen revealed gastric carcinoma with lymphoid stroma on hematoxylin and eosin staining, and the tumor cells were positive for the in situ hybridization of Epstein-Barr virus (EBV) -encoded small RNAs. Enhanced computed tomography images revealed no metastasis to lymph nodes and other organs in the chest and abdomen. Therefore, the diagnosis was gastric carcinoma with lymphoid stroma-associated EBV (clinical stage IA), and surgery was performed. The frequency of EBV-associated carcinoma is not small and it has poor subjective symptoms; hence, its discrimination by characteristic clinical pathology findings is necessary.
