An 87-year-old man was diagnosed with ampullary adenoma based on an upper gastrointestinal endoscopy screening. Endoscopic papillectomy was recommended, but the patient refused. Six years later, he visited the hospital presenting with symptoms of cholangitis, and an upper gastrointestinal endoscopy revealed an enlarged ampullary tumor. We performed a biopsy and diagnosed the patient with an adenocarcinoma. Since he did not agree to a surgery, we performed palliative endoscopic biliary drainage using a self-expandable metallic stent (SEMS).
The origin of the ampullary adenoma remains unclear. We experienced a case in which an adenoma developed into cancer over a long period of 6 years. We will eventually report the case along with a review of literature.
