A man in his 60s came to our hospital with reduced sensation of his right extremities, as well as a disordered sense of taste, and appetite loss. A red smooth tongue was observed that suggested Hunter's glossitis. Laboratory data revealed macrocytic anemia with vitamin B12 deficiency and hypergastrinemia. Parietal cell antibody and intrinsic factor antibody were positive. Helicobacter pylori IgG antibody was negative. Endoscopic findings showed atrophic change of the fundus and corpus. Endocrine cell micronests were identified by immunohistochemical staining. From these findings, he was diagnosed with autoimmune gastritis with pernicious anemia. Oral vitamin B12 1500 μg daily was effective for the physical findings and anemia. Because autoimmune gastritis is a risk factor for gastric cancer and neuroendocrine tumor, periodical endoscopic surveillance should be performed.
