1993 Volume 42 Pages 143-147
Pure pancreatic juice (PPJ) was collected from 42 cases by the endoscopic retrograde cannulation through the papilla from January 1990 to September 1992. Samples were collected every 5 minutes for 20 minutes after rapid intravenous injection of secretin (100 units, Eisai) .
They were divided into 4 groups according to the clinical classification of chronic pancreatitis (CP) based on the criteria detected by the Japanese Society of Gastroenterology. They were compared with studies on pancreatic exocrine secretions (volume, maximal bicarbonate concentrations, amylase out put, lipase concentrations, trypsin concentrations) by means of biochemical analysis of endoscopically collected PPJ. The results are expressed as arithmetic means (±SD) . They were compared by Kruskal-Wallis test and Wilcoxon rank-sam test. A two-tailed P value less than 5% was considered to indicate statistical significance.
Patients with Group 1 (definite CP) showed significantly lower maximal bicarbonate concentrations than those with Group 2 (clinical CP) . Patients with Group 1 showed significantly lower volume and maximal bicarbonate concentrations than those with Group 3 (probable CP) . Patients with Group 1 and Group 2 showed significantly lower lipase concentrations than those with Group 4 (free of CP) .
In conclusion, it should be said that means of biochemical analysis of endoscopically collected PPJ was more reliable to evaluate pancreatic exocrine secretions with CP.
