1994 Volume 44 Pages 127-129
A 35-year-old Japanease female was admitted to our hospital in June 1993 because of abdominal pain and nausea of a month's duration. She had been suffering from bronchial asthma since autumn of 1991.
Laboratory examination on admission revealed leukocytosis, eosinophilia, thrombocytosis, increased erythrocyte sedimentation rate, elevated concentration of plasma immunoglobulin E and positive RA test. Colonoscopy disclosed multiple erosions and map-like, irregular ulcers with reddish mucosa of rectum through descending colon. Histological examination of biopsy specimen showed marked eosinophilic infiltration into ulcerated mucosa. Two weeks after hospitalization, muscle weakness and numbness of extremities due to multiple mononeuropathy occurred.
After starting steroid pulse therapy, number of leucocytes and eosinocytes became normal and rapid improvement of her symptoms were recognized. Re-examination of colonoscopy and biopsy showed neither ulceration nor eosinophilic infiltration.
Although reported cases of Churg-Strauss syndrome have been increasing, those with colonic disease are rare and only 7 cases were reported for latest 5 years in Japan.
