1995 Volume 47 Pages 130-131
We studied on : (1) the Helicobacter pylori (Hp) eradication rate and side effects (2) the association between eradication and inflammatory reaction of gastric mucosa and (3) the correlation between serum anti-CagA antibody titer and gastric diseases. Patients formed two groups : twenty-one patients in group A recieved lansoprazole (L) 30mg, plus clarithromycin (CAM) 400mg, for two weeks ; twenty-six patients in group B were treated with L 60mg, plus CAM 800mg for two weeks.
Results : (1) Using a 13C-urea breath test instead of a conventional method including CLO, culture and histology, measured eradication rates fell from 43% to 19% in group A, from 58% to 31% in group B. Side effects rose in frequency as dosage increased. (2) After eradication, levels of IL-8 and myeloperoxidase (MPO) in gastric mucosa improved. There was no correlation between inflammation severity before eradication and eradication rate. (3) Serum anti-CagA antibody titer rose in patients with open ulcers and was significantly high in Hp-infected patients with. Changes in antibody titer after eradication may reflect changes in microorganism volume and host reaction.
