1997 Volume 50 Pages 147-151
We evaluated the endoscopic findings and histopathological data after eradication of Helicobacter pylori (HP) . One hundred and two HP-positive patients consisted of 30 gastric ulcer, 23 duodenal ulcers, 11 gastroduodenal ulcers and 38 chronic gastritis were treated. Fifty-five patients were treated with 600mg of clarithromycin (CAM) , 30mg of lansoprazole (LAZ) and 2.0g of ecabet sodium (E-Na) in a day for 14 days (A group) . Fourty-seven patients treated with 2000mg of amoxicillin (AMPC) , 30mg of LAZ and 2.0g E-Na in a day for 14 days (B group) .
Endoscopy was performed before and after eradication. Each two gastric biopsies were collected from site of upper body, lower body and antrum in greater curvature. One piece was examined for HP-culture and other was used for the pathological study. 13C-urea breath test (UBT) was performed using 100mg of 13C-labelled urea. Expiration was collected at 0, 5, 10, 20, 30, 60 minutes and 13CO2/12CO2 was measured by laser spectroscopy. UBT was carried out before and 0, 2, 4, 12 weeks after treatment.
HP was eradicated in 70.5% (72/102) . 54.5% in A group and 89.3% in B group were eradicated. In endoscopic study before treatment, low grade of flat erosive gastritis showed in effective cases compared with non-effective cases. Erythematous gastritis improved after eradication of HP. In histopathological study, neutrocyte and monocyte infiltration were improved after treatment.
In conclusion, AMPC group (B group) demonstrated higher effective than CAM group (B group) . UBT can be useful in observing presence of HP in the stomach after treatment.
