1997 Volume 50 Pages 266-267
Recently, it has been reported that Helicobacter pylori (H. pylori) infection refered to the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, because MALT lymphoma was improved by eradication of H. pylori.
This patient was a 56-years-old man. Barium meal examination showed a small depressed lesion in the middle body of the stomach. Endoscopic examination revealed a scattered irregular depressed lesion in the same location. Histological study of the biopsy specimen revealed proliferation of atypical lymphoid cells and lympho-epithelial lesions in the gastric mucosa, and the diagnosis of gastric MALT lymphoma was suggested.
H. pylori was detected by both culture and histological findings. So, we tried antibiotic therapy for H. pylori by 30mg of lansoprazole, 1500mg of amoxicillin, and 400mg of clarithromycin for 2 weeks. Six months after the therapy, eradication of H. pylori was ascertained and the MALT lymphoma lesion had disappeared endoscopically and histologically. It is suggested that H. pylori infection play a role in the pathgenesis of gastric MALT lymphoma, and that eradication of H. pylori is the first choice treatment for gastric MALT lymphoma.
