1997 Volume 50 Pages 272-273
The patient was a 62-year-old woman. In 1984, she was pointed out to have a 5mm-sized polyp in the upper body of stomach and it was diagnosed as hyperplastic polyp by a biopsied specimen. The polype enlarged to 10mm in diameter over the next 12 years and its endoscopic appearance changed to lobulated and variegated one.
Since histological findings of biopsied specimens in 1996 showed adenocarcinoma, polypectomy was performed. Microscopic study of the resected specimen demonstrated well-defferentiated adenocarcinoma located on the surface of hyperplastic polyp. This is a very rare case of gastric hyperplastic polyp accompanied by the malignant transformation recognized by serial endoscopy during follow-up for 12 years.
This case suggests that enlargement and lobulating tendency could be considered as sings of malignant transformation of hyperplastic polyps. Diagnostic reliability of biopsy could not be always perfect in case of malignant transfomation of gastric hyperplastic polyp, therefore, endoscopic follow-up should be performed continuously. When the signs indicated above are observed, endoscopic polypectomy should be applied regardless of negativeresults of biopsied specimens.
