Abstract
A 48-year-old man visited our hospital for medical checkup. X-ray and endoscopic examinations revealed multiple polypoid lesions in his esophagus, stomach, duodenum and colorectum. He had facial papules and papillomatous oral lesions, and was diagnosed as Cowden's disease.
Cowden's disease is characterized by multiple hyperplastic or hamartomatous lesions originating from three embryonic germ layers in the whole body. This disease is frequently complicated with malignant tumors and should be considered in the differential diagnosis of gastrointestinal polyposis syndromes.
