Abstract
Dextranase was obtained from Spicaria violaceae (IFO 6120), and a study was carried out to determine whether the mouth rinsing with a dextranase was effective in the removal or prevention of dental plaque in man.
1) The study was done using a dextranase new drug and inactive control by double blind method.
2) The men of each group were rinsed for 3 days, 4 times a day. The dextranase rinsing groups (100, 000, 50, 000, or 10, 000 dextranase units at a rinsing time) were compared with the placebo group in dry weight of plaque deposits on the buccal tooth surface from the maxillary first premolar to the second molar.
3) The results of an analysis of variance showed significant difference at 5 per cent lebel between the 100, 000 units dextranase rinsing group and the placebo group. Contribution rate of the dextranase was 33 per cent.
4) There was not significant difference between the 50, 000 or 10, 000 units dextranase rinsing group and the placebo grop. Contribution rate of the dextranase, however, was 11 per cent.
5) No harmfull effects with the dextranase were recognized.
