Abstract
The mouthrinses be carried out for prevention and inhibition of periodontal diseases and dental caries. Clinical studies have shown that mouthrinses with 0.2 per cent solution of Chlorhexidine prevent the formation of dental plaque (Löe and Schiött). This clear preventive effect of dental plaque formation considered that Chlorhexidine had strong bactericidal action and antibacterial durability.
The purpose of the present study was to compare to what contents the sialic acid of human mixing saliva were influencened by Chlorhexidine and each mouth-washs be on the market (Acrinol, Oradol and Lavoris).
The author carried out the experiments as follows: In vitro, variations of sialic acid contents were compared to influence in cases that 0.2 per cent solution of Chlorhexidine and other mouth-washs be on the market which were annexed to human mixing saliva and then collected from the subjects.
In vivo, it observed that the variations of sialic acid contents at interval of an hour from 8:30a.m. to 5:30p.m. by mouthrinses with 0.2 per cent solution of Chlorhexidine after taking regular meal.
Forty males dental student, 19 to 24 years of age included in these investigations.
Quantitative analysis of sialic acid contents was colourimetric determination by Aminoff's method.
The following conclusions are to be drawn.
1. In vitro, sialic acid decreased in saliva after 0.2 per cent of Chlorhexidine used that was more than other mouth-washs be on the market.
2. In vivo, sialic acid contents indicated considerable decrease in which mouthrinses with 0.2 per cont solution of Chlorhexidine after taking regular meal, but this value retrieved about one hour.
3. From the above, Chlorhexidine used for salivary mucin reduction, is due to effectiveness in inhibiting of dental plaque formation. The continuous usage was advised because the effective duration is limited.
