Abstract
The effectiveness against periodontal disease of a dentifrice containing dl-α-tocopheryl nicotinate (V dentifrice) was tested comparing with placebo (P dentifrice) for 4 weeks.
Subjects were 165 students of Josai Dental University who had no serious oral disease.
This study was conducted with double blind method.
The results were summarized as follows.
1) Subjects available for statistical analysis were 67 in each group. Subjects unavailable for statistical analysis were 16 in V dentifrice group and 15 in P detifrice group.
2) V dentifrice was significantly superior to P dentifrice in improvement of PMA index (p<0.01) and redness (p<0.01). On the other hand, there was no significant difference in improvement of dental plaque and swelling between two groups.
3) After 4 weeks of the study, reduction rate of Vdentifrice group and P dentifrice group were 40.6% and 27.1% in PMA index, 17.0% and 9.1% in redness, 13.7% and 5.9% in swelling, and 4.5% and 4.7% in dental plaque, respectively.
4) V dentifrice was significantly superior in general improvement to P dentifrice (p<0.01).
The percentage of generally improved subjects of V dentifrice group and P dentifrice group were 77.6% and 56.7%, respectively.
5) No particular side effect was obserbed throughout the study.
