1992 Volume 34 Issue 1 Pages 125-132
This study was carried out in order to develop a new implantable biomaterial possessing osteogenetic ability. We prepared a bone morphogenetic protein (BMP) -atelocollagen gel complex, and investigated its osteoinductive properties. BMP was extracted from bovine cortical bones. The BMP-atelocollagen complex or a BMP-saline control was injected to the muscle pouches of mice, and the calvaria of rats. Osteoinduction was examined on the 7th and 21st days after implantation in order to assess osteoinductive ability. New bone formation was studied by roentgenographic and histologic observation. In the BMP-atelocollagen complex group, new bone formation was seen on roentgenogram and new cartilage and bone were observed histologically. In the BMP-saline gorup, neither new cartilage nor bone formation was noted. In conclusion, atelocollagen seems to be a very effective carrier of BMP and this delivery system has great potential in the application of new treatments for periodontal disease.
