Clinical Screening Test for Thrombophilic Predispositions

Abstract

Prevention of deep vein thrombosis (DVT) is a key to avoid pulmonary embolism (PE), that is a postoperative fatal complication. Number of patient with postoperative DVT and PE is increasing in Japan with a wide recognition of its pathophysiology.

Screening test is important to find out patients with a thrombophilic redisposition; Protein C deficiency, Protein S deficiency, Anti-thrombin deficiency and positive anti cardiolipin- β2- Glycoprotein 1 antibody. These were examined routinely before major surgery and femoral catheter procedure in Nagoya University Hospital. This paper is a brief summary of these thrombophilic predispositions.