The Journal of Physiological Sciences
Regular Papers
Acupuncture Inhibits Kainic Acid–Induced Hippocampal Cell Death in Mice
Seung-Tae KimSonghee JeonHae Jeong ParkMee-Sook HongWu Byung JeongJang-Hyun KimYeonjung KimHye-Jung LeeHi-Joon ParkJoo-Ho Chung
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Volume 58 (2008) Issue 1 Pages 31-38

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We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)–induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 μg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions.

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© 2008 by The Physiological Society of Japan
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