Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
ISSN-L : 0386-2208
Review
Induction of pluripotency by defined factors
Koji TANABEKazutoshi TAKAHASHIShinya YAMANAKA
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2014 Volume 90 Issue 3 Pages 83-96

Details
Abstract

The “reversion of cell fate from differentiated states back into totipotent or pluripotent states” has been an interest of many scientists for a long time. With the help of knowledge accumulated by those scientists, we succeeded in converting somatic cells to a pluripotent cell lineage by the forced expression of defined factors. These established induced pluripotent stem (iPS) cells have similar features to embryonic stem (ES) cells, including pluripotency and immortality. The iPS cell technology provides unprecedented opportunities for regenerative medicine and drug discovery.

Information related to the author
© 2014 The Japan Academy
Next article
feedback
Top