Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
ISSN-L : 0386-2208
Current issue
Displaying 1-2 of 2 articles from this issue
Review Series to Celebrate Our 100th Volume
  • Hidenori MIMURA
    2024 Volume 100 Issue 5 Pages 281-292
    Published: May 10, 2024
    Released on J-STAGE: May 10, 2024

    Magnetron production and use far exceed that of other microwave tubes due to their high operational efficiency, power efficiency, and cost-effectiveness in production. The magnetron was named by A. W. Hull; however, the device invented by Hull differs from the magnetron utilized as a microwave tube. The magnetron widely used today is based on the split-anode magnetron invented by K. Okabe. This overview introduces two papers published by Okabe in the Proceedings of the Imperial Academy and discusses the events that led to the discovery of the split-anode magnetron. In addition, the operation mechanisms of magnetrons are explained.

  • Tomohiro KUROKAWA, Kohzoh IMAI
    2024 Volume 100 Issue 5 Pages 293-308
    Published: May 10, 2024
    Released on J-STAGE: May 10, 2024

    Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emerged as a promising target, especially in light of advances in chimeric antigen receptor (CAR) T-cell therapy. The profound bioactivity of CSPG4 and its role in pivotal processes such as tumor proliferation, migration, and neoangiogenesis underline its therapeutic potential. We reviewed the molecular intricacies of CSPG4, its functional attributes within tumor cells, and the latest clinical-translational advances targeting it. Strategies such as blocking monoclonal antibodies, conjugate therapies, bispecific antibodies, small-molecule inhibitors, CAR T-cell therapies, trispecific killer engagers, and ribonucleic acid vaccines against CSPG4 were assessed. CSPG4 overexpression in diverse tumors and its correlation with adverse prognostic outcomes emphasize its significance in cancer biology. These findings suggest that targeting CSPG4 offers a promising avenue for future cancer therapy, with potential synergistic effects when combined with existing treatments.