Bile Acid Composition and Liver Function in Pancreatitis

Abstract

(1) In the case of pancreatitis, free bile acids in biles increase and the proportion of cholic acid decreases, as compared with the values of normal person. This situation is quite similar to that in the case of patient with cholelithiasis.
(2) In the bile of dogs with experimental pancreatitis, free bile acids are also increasing and the proportion of cholic acid is decreasing, as compared with the values of normal dogs.
(3) Histozyme activity in liver was found to increase in the dogs suffering from experimentally induced acute pancreatitis.
(4) It appears, therefore, that pancreatitis induces some kind of liver function disorder, which causes a change of bile acid composition, thus forming a gall stone.