An Autoradiographic Investigation of the Chromosomes Showing a D/D Translocation

Abstract

A chromosome translocation involving two D chromosomes was found in 2 patients, one a phenotypically normal female (case 1) who experienced 3 consecutive abortions and the other a male (case 2) with hypogonadism. Autoradiographic analyses strongly indicated that the abnormal metacentric chromosome was resulted from the centric fusion between D13 and D14 chromosomes in both cases. It appears that the translocation per se does not deal with phenotypical anomalies.