Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
Dynamic Expression of αB-Crystallin in Skeletal Muscle
Effects of Unweighting, Passive Stretch and Denervation
Yoriko ATOMIShigeru YAMADAYeong-Man HONG
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1990 Volume 66 Issue 10 Pages 203-208


Twenty-two kDa protein specifically decreased in slow soleus muscle atrophy after 2-week hindlimb suspension (HS) of rats. This protein is abundant in soleus muscle but less in fast plantaris muscle. We purified this protein, determined the partial amino acid sequence using its proteolytic fragment, and found that the 22-kDa protein was a α-crystallin B chain with a 95% homology to bovine αB-crystallin. Further we demonstrated that αB-crystallin did not decrease in passively stretched slow muscle even under HS, and did markedly increase in denervated and stretched fast muscle under HS. These results suggest that the expression of αB-crystallin is dynamically related to the muscle plasticity.

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