Genomic DNA shuffling in archaebacteria
Comparison of the genomes of two Pyrococcus species
1999 年 75 巻 1 号 p. 10-15
詳細
1999 年 75 巻 1 号 p. 10-15
The complete genomic DNA sequence of a hyperthermophilic archaebacterium, Pyrococcus sp. OT3, of the length of 1, 738, 505bp (Kawarabayasi et al., 1998, DNA Res. 5, 55-57) has been compared with the nearly complete genomic DNA sequence of a related species, Pyrococcus furiosus, of the length of 1, 744, 644bp (deposited in the Utah genome center database, http://www.genome.utah.edu). Approximately 60 segments of the lengths close to 20kbp on average are idendified to be shared by the two genomes but in different orders. Approximately half of the segments are oriented in the opposite directions in the two genomes. Approximately two thirds of the segments are found relatively shifted in the two genomes only by 200kbp or shorter. It is likely that translocation of DNA segments has been one of the important mechanisms to drive the evolution of archaebacterial genomes.
