Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

Mitsuko MASUTANI; Takashi SHIMOKAWA; Masayuki IGARASHI; Masa HAMADA; Atsushi SHIBATA; Sachiho OAMI; Tadashige NOZAKI; Hitoshi NAKAGAMA; Takashi SUGIMURA; Tomio TAKEUCHI; Makoto HORI

doi:10.2183/pjab.78.15

Mitsuko MASUTANI, Takashi SHIMOKAWA, Masayuki IGARASHI, Masa HAMADA, Atsushi SHIBATA, Sachiho OAMI, Tadashige NOZAKI, Hitoshi NAKAGAMA, Takashi SUGIMURA, Tomio TAKEUCHI, Makoto HORI

著者情報

Mitsuko MASUTANI
Biochemistry Division, National Cancer Center Research Institute
Takashi SHIMOKAWA
Biochemistry Division, National Cancer Center Research Institute
Masayuki IGARASHI
Institute of Microbial Chemistry
Masa HAMADA
Institute of Microbial Chemistry
Atsushi SHIBATA
Biochemistry Division, National Cancer Center Research Institute
Sachiho OAMI
Biochemistry Division, National Cancer Center Research Institute
Tadashige NOZAKI
Biochemistry Division, National Cancer Center Research Institute
Hitoshi NAKAGAMA
Biochemistry Division, National Cancer Center Research Institute
Takashi SUGIMURA
Biochemistry Division, National Cancer Center Research Institute
Tomio TAKEUCHI
Institute of Microbial Chemistry
Makoto HORI
Institute of Microbial Chemistry

キーワード: Poly(ADP-ribose) glycohydrolase, pargamicin, PD124,966, cyclic peptide, inhibititor

ジャーナルフリー

2002 年 78 巻 1 号 p. 15-17

DOI https://doi.org/10.2183/pjab.78.15

詳細

抄録

A member of the cyclic hexadepsipeptide family, PD124, 966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC₅₀ of 40μg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC₅₀ of 28μg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.

責任著者(Corresponding author)

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