抄録
The age-related modification of intestinal fat absosption was studied in 17 early newborns (0-7 days of life), 12 late newborns (8-20 days of life) and 14 infants (1 month-2 years old).
Capillary chylomicron counts (Takagi's method), serum β-lipoprotein percent concentration (Swahn's method), serum cholesterol concentration (Zurkowski's method), blood glucose level (glucose oxidase method) were measured in fasting and 1, 2, 3, and 4 hours after the oral administration of mixtured oil emulsion containing equal amounts of colza oil and soya bean oil.
The increases in the chylomicron counts which were observed after the oil administration were more remarkable in the late newborns and infants than in the early newborns. The increased particles of chylomicron mainly consisted of dull particles. The change in β- lipoprotein level after the oil administration was as marked as that in chylomicron counts. However, the cholesterol concentration did not change significantly in both of the newborns and infants. The blood glucose level after the oral administration of the oil emulsion increased significantly in the early newborns, but not in the late newborns and infants.
It is concluded that the early newborns are less capable of absorbing fat than the late newborns and infants, and that the fat absorption from the intestine, which increases with aging, is related with carbohydrate metabolism during the first 7 days of extra-uterine life.
