Colibacillus (B. coli) is closely related with the human body, because it exists in every environment where the humans live. It has been experimentally proved by us that due to their anatomical and functional characteristics women are not infrequently sufferers from illness caused by invasion of this organism into their urogenital organs. By means of kauffmann's serological method as well as those which were previously known, we have made studies which may be as follows 1 The O-sero-types was determined for coli bacilli taken from the vagina and intestinal canal as well as from urine collected from the urinary bladder of patients whose urinary tract were infected with this orgamism. 2. The frequency of appearance of this organism in the vagina and conditions related to its habitation were investigated. 3. Studies were made on the presence in the vagina of this bacillus and its relation to those in the intestinal canal. 4. Influences on the coli bacillus in the vagina undergoing surgical operations and radiotherapeutics were also studied. 5. Effects of antibiotics on colonies of this organism in the vagina and intestinal canal were also investigated. 6. This bacillus was examined as a causative organism of infection of the urinary tract. 7. Studies were made on sensitivities and resistance to antibiotics of the bacillus isolated from the vagina and urine. The results obtained from these various studies are presented together with a review of the importance of the colibacillus in the field of obstetrics and gynecology.