抄録
The fluctuation of the serum ICG level and its biliary excretion were examined after intravenous injection of the drug. Results were summarized as follows :
1) Blood level of ICG seemed to be influenced by the fluctuation of the blood pressure.
2) In normal cases, biliary ICG appeared as early as 5 to 10 minutes after injection, reached it maximum after 60 to 90 minutes and then gradually diminished. However, in cases with impaiered hepatic function, it appeared and reached maximum more slowly.
3) With the fluctuating curve of biliary ICG concentration, the rates of increasing and decreasing biliary ICG excretion, are designated by the present author as Ka and Ke, respectively, reffering the rate of decreasing blood ICG, K. In cases ranging normal K values, the mean Ka was 5.3 per cent/min, and the mean Ke was 0.38 per cent/min.
4) Ka values correlated closely to icterus index, but not to the activity of serum alkaline phosphatase and the titers of serum colloidal reaction tests.
5) The relation betweeh Ka and K was well corresponded, i. e. Ka was distributed below 4.0 per cent/min in cases K was less than 0.1 per cent/min. The K values could be accepted as the index of hepatic function, because these two indexes indicating the hepatic uptake and biliary excretion of ICG were fairly well correlated, while Ke values did not correlated to K values.
