A study of Quantitative Analysis and Pathogenesis of Pancreatic Lithiasis.

--An Autopsy Case of Pancreatic Lithiasis with small Cancer of the Head--

Abstract

Quantitative analysis and histopathological examination of pancreatic lithiasis were done for the purpose to clear the pathogenesis of the stone formation. Our results and references from the literature suggest that the stone should be made after stagnation and concentration of pancreatic juice with trigger action such as chronic alcoholism, chronic relapsing pancreatitis and cancer of pancreas head. The main component of the stone is calcium salts (34%) and a few of Mg, Zn and Phosphate are recogized. Typical histopathological changes of pancreatic lithiasis was observed with late stage of chronic pancreatitis called pancreatic fibrosis. 1. Dilatation of small pancreatic ducts with marked neutrophilic infiltration and abscess formation. 2. Granulation tissues, bleeding and deposition of hemosiderin particles in the duct wall. 3. Marked atrophy and fibrosis of acini and a few of Langerhans islets remained. The remaining islets were often hypertrophic. 4. Marked perineural lymphocytic proliferation were observed, some makes lymphoid follicles.