Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
A Cytological Study of the Exfoliative Cells from Pancreatic Duct
-Special Reference to the Differentiation of Atypical Cells of Chronic Pancreatitis and Pancreatic Cancer Cells-
HIROFUMI GONDA
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1978 Volume 24 Issue 2 Pages 144-159

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Abstract
Considerable difficulty is sometimes encountered in cytodiagnostic differentiation of atypical cells in chronic pancreatitis from pancreatic cancer cells. To obviate such a difficulty, an endoscopic intraductal brushing method has been devised to collect sufficient exfoiated epithelial cells from the pancreatic duct. A cytomorphologic study of exfoliated epithelial cells has been carried out in normal, mild chronic pancreatitis, advanced chronic pancreatitis and pancratic carcinoma cases. The incidence of atypical cells was related to the grade of panereatitis. In normal case and midi chronic pancreatitis, the indidence of atypical cells was decreased and in advanced chronic pancreatitis was it increased. The findings of atypical cells in these cases were similar to the malignant cells whicr must be differenciated strictly from atypical cells. The cells measuring more than 20μ in cellular diameter and over 18μ in nuclear diameter were not demonstrated in any of the advanced cases of chronic pancreatitis. Another point of diagnostic importance consists of marked anisokaryosis, nuclear atypism, abnormal overlaping, and anisochromatism.
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© 1978 The Juntendo Medical Society
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