Abstract
Morphological examinations of normal cells, benign atypical cells and carcinoma cells of the biliary tract, obtained by the PTCD brushing method, were performed. Cells examined included those from 23 cases of cancer and 13 cases of benign disease.
1. Cell findings : The predominace of the overlapping of malignant cells over benign cells. Anisocytosis and anisonucleosis were found to be more dominant than normal cells and less than the carcinoma cells.
2. The size of cells and the nucleus : In carcinoma cells and benign atypical cells, the nucleus was larger than in normal cells. The difference between the carcinoma and the beinign atypical cells was not stastically significant.
3. The nuclear contour : In carcinoma and benign atypical cells, the nuclear contour was thickened, and more predominant and irregular in carcinoma cells.
4. Nuclear chromatine : The nuclear chromatine was coarsely condensed in both the benign atypical cells and carcinoma cells, but its distribution was highly irregular in carcinoma cells.
5. The size and number of nucleoli : The number was identical to those found in benign atypical cells and in carcinoma cells. The size, however, appeared conspicuously larger in the carcinoma cells than in the benign atypical cells.
The above mentioned conculusions were confirmed by statistics which numerate the various (9) cell findings.
