Abstract
The relationship between the serum level of group 1 pepsinogen (PG1) and gastric end-exocrine activity in patients with peptic ulcer were studied in 51 patients (26 normosecretors [group N] with MAO below 20 mEq/hr and 25 hypersecretors [group H] with MAO above 20 mEq/hr) and 37 controls by various loading tests. A positive correlation was obseved between the serum PG1 level and gastric acid secretion during stimulation with betazole hydrochloride and insulin, suggesting the involvement of a cholinergic factor in serum PG1 secretion. Also, gastrin and secretin were considered to be involved in the synthesis and secretion of serum PG1, the former in group N and the latter in both groups N and H.
