Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Effect of FK-506, Ciclosporin on the survival of corneal grafts in rabbits
CHIHIRO KOBAYASHI
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1990 Volume 36 Issue 2 Pages 189-196

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Abstract
In an assessment of the immunosuppressive efficacy of FK-506 following corneal allograft transplant surgery preceded subconjunctival injection of either FK-506 or Ciclosporin (CYA) eye drops and topical administration of both FK-506 and CYA. For FK-506, survival rates were as follows : exchange keratoplasties (0.1mg/Kg twice a week), 100% at 100 days ; re-keratoplasties (0.1mg/Kg twice a week), 88% at 100 days ; and exchange keratoplasties (0.01mg/Kg once a week), 100% at 200 days. For CYA, survival rate exchange keratoplasties (0.025% 4 times a day) was 100% at 100 days, and that of re-keratoplasties (0.025% 4 times a day) was 66% at 40 days. Even topical administration of FK-506 and CYA together suppressed allograft rejection of experimental keratoplasties. We found that topical administration of FK-506 and CYA may be an effective immunosuppressant in clinical keratoplasties.
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© 1990 The Juntendo Medical Society
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