Abstract
Peripheral blood levels of Adriamycin (ADR) after intrahepatic arterial administration were compared with those after intravenous administration in dogs. The effect of combined plasma exchange with intrahepatic arterial administration on the peripheral blood level of ADR was also studied pharmacokinetically. For this study 9 adult mongrel dogs were divided in to 3 groups for intravenous administration, intrahepatic arterial administration and intrahepatic administration with plasma exchange. The pharmacokinetics of AD R was evaluated by the trapezoidal rule. The mean area under the curve up to 30 min after administration (AUC5→30) was 3.66μg/ ml/ min in the intrahepatic administration group and 4.89μrg/ ml/ min in the intravenous administration group, showing a slightly lower level in the intrahepatic aretrial administration group. The mean area under the curve from 30min to 120 min after administration (AUC30→120) was 3.33μg/ ml/ min in the intrahepatic arterial administration group and 2.85μg/ ml/ min in the intravenous administration group, showing a higher level in the intrahepatic arterial administration group. The overall mean AUC (AUC5→120) was 6.98μg/ ml/ min in the intrahepatic arterial administration group, being similar to that of the other groups.
These findings showed that a considerable amount of the ADR leaked systemically after passing through the liver by intrahepatic arterial administration.
The AUC5→30 in the intrahepatic arterial administration with plasma exchange group was 3.66μg/ ml/ min, which was similar to the level in the intrahepatic arterial administration group. However, the AUC3 in the group, was as low as 3.33μrg/ ml/ min, which indicates that about 2.3μg/ml/ min (about 44% of UC5→120) of ADR was eliminated by plasma exchange.
