Abstract
The expressions of DAF and CD59 on the leukocytes were analyzed by FACStar in 20 patients with hemotological malignant disorders (MDS : 11 patients, AML : 3 patients, CML : 4 patients, T-LGLL : 1 patient, CLL : 1 patient).
The expression of DAF decreased in four patients and increased in seven patients with MDS, whereas the expression of CD59 increased in 9 patients.
The expression of CD59 on the peripheral blood cells and bone marrow cells was studied in a patient with MDS. The expession of CD59 varied among different bone marrow cells, whereas that on peripheral blood cells was high. These findings indicated that dishaemopoiesis was caused on bone marrow cells with low expression of CD59 in patients with MDS.
The expressions of DAF and CD59 increased in a CML patient with marked leukocytosis, whereas those decreased in two patients whose WBC counts were well controlled by interferon in a case wihout treatment. The expressions of DAF and CD59 decreased on T lymphocytes from a patient with T-LGLL, particularly, decreased expression of DAF was striking.
The expressions of DAF and CD59 on the lymphocytes seem to resemble that on NK cells, suggesting the importance of discussing the origin of T-cell and NK cell.
