Abstract
Glycolysis-power of erythrocytes in hemolytic disease have been investigated. Differences of glucose-, lactic acid-, and pyruvic acid concentration in blood of healthy man, of anemia with poor hemoglobin, of accquired hemolytic anemia, or of experimental hemolytic anemia before and after shaking for 60 min. at 37°C in aerobic and anaerobic condition adding heparin were compared and their relations to the lives of erythrocytes in each blood were also investigated.
In accquired hemolytic anemia, the power of glycolysis obviously increases as compared with that of healthy man or anemia of poor hemoglobin, and the lower the power of glycolysis transfused into healthy man is, the shorter the life of erythrocyte is. In experimental hemolytic anemia, the power increases greatly and the life of erythrocyte is normal for 3-6 hrs. after the injection of antisera to blood cells, but after 12hrs. the power decreases to a extent lower than normal state and the life of erythrocyte is also shortend. Those relations between the powers of glycolysis and the lives of erythrocytes in clinical and experimental hemolytic anemia imply the accelerated declining of erythrocytes in such a disadvantageous condition that they are accompanied with antibodies.
