抄録
Ammonia metabolism was studied in 19 normal patients and 24 patients with liver dysfunction.These results were confirmed experimentally in dogs.
1. The blood ammonia levels were determined in patients without liver disease, with hepatitis, livercirrhosis, and hepatic coma.
In livercirrhosis and hepatic coma the blood ammonia levels were found to be remarkably elevated.
2. Ammonia chloride tolerance test was performed in these patients.
Curves of blood ammonia levels in livercirrhosis were different from hepatitis and normal.From these results it was concluded that serious dysfunction of ammonia metabolism is present in patients with livercirrhosis.
3. High levels of blood ammonia arise from the failure of liver, and from the formation of collateral channels of the portal vein. These relationships were confirmed experimentally in dogs with portal venous stricture and liver damage by carbon tetrachloride.
4. In these cases blood suger, pyruvic acid, lactic acid etc were also determined. From these results it was supposed that the citric acid cycle were also interfered, but not only ammonia metabolism.
5. When glutamic acid were used in the high levels of blood ammonia, the ammonia level fell and improved the derangement of glycolytic ability
