Abstract
A 65-year-old man with chronic hepatitis C received interferon (IFN) therapy and a good outcome was achieved after IFN. Thirst and weight loss was presented and his postprandial plasma glucose and glycosylated hemoglobin (HbA1C) levels increased. Dietary therapy and oral hypoglycemic agents improved glucose and hemoglobin to moderate levels. He was positive for anti-glutamic acid decarboxylase (anti-GAD) antibody 29 months after IFN therapy and required insulin therapy because of the positive anti-GAD antibody and development of severe hyperglycemia. Insulin gradually improved his glycemic level. We report a case of insulin-dependent diabetes mellitus with anti-GAD antibody which developed after IFN therapy for chronic hepatitis C.
