Abstract
Objective : The effect of alpha-1 blocker on various parameters of benign prostatic hyperplasia were studied.
Methods : Studies were carried out on thirty-three patients with BPH. These patients were given alpha-1 blocker at our university hospital for one month each between July 2003 and March 2004. Tamsulosin and Naftopidil were administered to six and twenty-seven patients, respectively. These patients were evaluated by patient age, PSA, International Prostate Symptom score (I-PSS), QOL score, prostate volume (PV), transition zone volume (TZV), TZ index (TZV/PV), h (intravesical prostatic protrusion), H/W (the ratio of the height/width of the maximal horizontal section of prostate on transrectal ultrasound), peak flow rate and residual urine after voiding within a month before medication. After each patient had received one month dose of medication, the effects were evaluated.
Results : Compared to other parameters, h, H/W and TZ index were better predictors of the effect of medication with alpha-1 blocker. Logistic analysis demonstrated h, H/W, TZ index strongly correlated with the therapeutic effects.
Conclusions : H / W, h, TZ index were useful in predicting the therapeutic efficacy of alpha-1 blocker for benign prostatic hyperplasia.
