Abstract
Objective : When a metal coil is used for coil embolectomy for patent ductus arterious or major collateral vessels, the long-term effect on the subject is an issue of concern. The development of a collagen coil made from atelocollagen that promotes self-organization after detainment but seems to heve negligible long-term effect was attempted, and histological changes in the coil and blood vessel by were examined animal experiments.
Materials and Methods : Twelve mongrel adult dogs weighing 9.8-12.0kg were used. The collagen coil was endoscopically implanted in adult the blood vessel (renal artery, carotid artery, vertebral artery) of an adult dog. Over the time course from 1 week to 5 years post detainment, blood vessels were collected, and the state of obstruction was observed, and the changes in the vascular lumen and coil were histologically examined.
Measurement and Results : A radiopaque collagen coil was produced for use in vascular occlusion and was able to be implanted successfully. After detainment for 5 years, the collagen coil was harvested and examined. The coil remained histologically complete and had induced perfect self-organization. Atelocollagen was an efficient material for the collagen coil and multiple factors seemed to be involved in the balance between the in vivo absorption rate and rate at which new organization was generated.
Conclusions : A coil for the vascular occlusion made from atelocollagen was successfully produced, and achieved perfect self-organization over a 5-year period of implantation. It seems that this experimental result indicates the possibility of a substitute for metal coils.
