The Effects of Aging and Exercise on Protein Acetylation/Deacetylation : Role of Sirtuins

抄録

Irreversible posttranslational modifactions of proteins play a key role in cellular regulation. Acetylation/deacetyltion of lysine residues not just turning on or switching off proteins, but it significantly could effect ubiquitination of the same lysine residues, hence the degradation of proteins. Aging is associated with decreased level of protein turnover, and our data indicates that the acetylation level of proteins is increased with aging, which supports the link between acetylation level and protein stability. Exercise training counteracts with the effects of aging on acetylation level and on the regulation of sirtuins, which are powerful protein deacetylators.